Director
Professor of Medicine in the Division of Experimental Medicine at UCSF.
Publications
Antiviral Monocytes Increase Prior to Detectable HIV-1 Rebound Viremia.
The Journal of infectious diseases
Peripheral immune progression to long COVID is associated with mitochondrial gene transcription: A meta-analysis.
Mitochondrion
Differential decreases in various HIV DNA regions and HIV transcripts after ART initiation during chronic infection.
Journal of virology
Phase I Trial to Evaluate the Safety of Intralesional Nivolumab Therapy for Limited Cutaneous Kaposi Sarcoma.
JCO oncology advances
Prevalence of Long COVID in Mycobacterium tuberculosis-exposed Groups in Peru and Kenya.
medRxiv : the preprint server for health sciences
Persistent immune dysregulation and metabolic alterations following SARS-CoV-2 infection.
medRxiv : the preprint server for health sciences
Targeting the SARS-CoV-2 reservoir in long COVID.
The Lancet. Infectious diseases
Longitudinal changes in the transcriptionally active and intact HIV reservoir after starting ART during acute infection.
Journal of virology
Galectin 9 Levels as a Potential Predictor of Intact HIV Reservoir Decay.
The Journal of infectious diseases
COVID-19 clinical presentation, management, and epidemiology: a concise compendium.
Frontiers in public health
Inflammatory Monocytes Increase Prior to Detectable HIV-1 Rebound Viremia.
bioRxiv : the preprint server for biology
Long COVID is associated with lower percentages of mature, cytotoxic NK cell phenotypes.
The Journal of clinical investigation
An Enhanced Role of Innate Immunity in the Immune Response After Kidney Transplant in People Living With HIV: A Transcriptomic Analysis.
Transplantation
Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV disease.
Nature communications
Transcriptomic Profiling of Human Myocardium at Sudden Death to Define Vulnerable Substrate for Lethal Arrhythmias.
JACC. Clinical electrophysiology
Post-SARS-CoV-2 Onset Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Symptoms in Two Cohort Studies of COVID-19 Recovery.
medRxiv : the preprint server for health sciences
Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
The promise and reality of new immune profiling technologies.
Nature immunology
Sirolimus reduces T cell cycling, immune checkpoint marker expression, and HIV-1 DNA in people with HIV.
Cell reports. Medicine
Rapid Biphasic Decay of Intact and Defective HIV DNA Reservoir During Acute Treated HIV Disease.
medRxiv : the preprint server for health sciences
Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort.
Annals of internal medicine
Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection.
Science translational medicine
[18F]F-AraG imaging reveals association between neuroinflammation and brown- and bone marrow adipose tissue.
Communications biology
Gaining momentum: stem cell therapies for HIV cure.
Current opinion in HIV and AIDS
Plasma-based antigen persistence in the post-acute phase of COVID-19.
The Lancet. Infectious diseases
Systems analysis of innate and adaptive immunity in Long COVID.
Seminars in immunology
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2.
Nature immunology
Association of nirmatrelvir for acute SARS-CoV-2 infection with subsequent Long COVID symptoms in an observational cohort study.
Journal of medical virology
Plasma-based antigen persistence in the post-acute phase of SARS-CoV-2 infection.
medRxiv : the preprint server for health sciences
The breadth of the neutralizing antibody response to original SARS-CoV-2 infection is linked to the presence of Long COVID symptoms.
Journal of medical virology
Association of SARS-CoV-2 Infection and Cardiopulmonary Long COVID With Exercise Capacity and Chronotropic Incompetence Among People With HIV.
Journal of the American Heart Association
Author Correction: SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).
Nature immunology
SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).
Nature immunology
SARS-CoV-2 Serology Across Scales: A Framework for Unbiased Estimation of Cumulative Incidence Incorporating Antibody Kinetics and Epidemic Recency.
American journal of epidemiology
Reduced Exercise Capacity, Chronotropic Incompetence, and Early Systemic Inflammation in Cardiopulmonary Phenotype Long Coronavirus Disease 2019.
The Journal of infectious diseases
Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2.
bioRxiv : the preprint server for biology
Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19.
medRxiv : the preprint server for health sciences
Effect of Immune-Modulatory Interventions on Asymptomatic Cytomegalovirus Shedding During Suppressive Antiretroviral Therapy.
The Journal of infectious diseases
Autoantigen profiling reveals a shared post-COVID signature in fully recovered and long COVID patients.
JCI insight
Association of SARS-CoV-2 Infection and Cardiopulmonary Long COVID with Exercise Capacity and Chronotropic Incompetence among People with HIV.
medRxiv : the preprint server for health sciences
MultiSero: An Open-Source Multiplex-ELISA Platform for Measuring Antibody Responses to Infection.
Pathogens (Basel, Switzerland)
The Breadth of the Neutralizing Antibody Response to Original SARS-CoV-2 Infection is Linked to the Presence of Long COVID Symptoms.
medRxiv : the preprint server for health sciences
Reduced exercise capacity, chronotropic incompetence, and early systemic inflammation in cardiopulmonary phenotype Long COVID.
medRxiv : the preprint server for health sciences
Autoantigen profiling reveals a shared post-COVID signature in fully recovered and Long COVID patients.
medRxiv : the preprint server for health sciences
Chronic viral coinfections differentially affect the likelihood of developing long COVID.
The Journal of clinical investigation
Differences in expression of tumor suppressor, innate immune, inflammasome, and potassium/gap junction channel host genes significantly predict viral reservoir size during treated HIV infection.
bioRxiv : the preprint server for biology
Low Prevalence of Interferon α Autoantibodies in People Experiencing Symptoms of Post-Coronavirus Disease 2019 (COVID-19) Conditions, or Long COVID.
The Journal of infectious diseases
PP 4.19 – 00021 Impact of SARS-COV-2-Mediated CD4 T Cell Activation HIV DNA Persistence In Vivo.
Journal of Virus Eradication
442. Clinical Outcomes of Checkpoint Inhibitor Therapy in People with HIV: A Single-Center Case Series.
Open Forum Infectious Diseases
P-41 In search of the HIV reservoir and a cure: translation of a CD30 imaging agent.
Nuclear Medicine and Biology
A common allele of HLA mediates asymptomatic SARS-CoV-2 infection.
medRxiv : the preprint server for health sciences
Differences in Post-mRNA Vaccination Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Immunoglobulin G (IgG) Concentrations and Surrogate Virus Neutralization Test Response by Human Immunodeficiency Virus (HIV) Status and Type of Vaccine: A Ma
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
COVID-19 in vaccinated versus unvaccinated hematologic malignancy patients.
Transplant infectious disease : an official journal of the Transplantation Society
Impact of Pre-Existing Chronic Viral Infection and Reactivation on the Development of Long COVID.
medRxiv : the preprint server for health sciences
Postacute sequelae and adaptive immune responses in people with HIV recovering from SARS-COV-2 infection.
AIDS (London, England)
Effect of Oral Nirmatrelvir on Long COVID Symptoms: 4 Cases and Rationale for Systematic Studies.
Pathogens & immunity
Plasma Markers of Neurologic Injury and Inflammation in People With Self-Reported Neurologic Postacute Sequelae of SARS-CoV-2 Infection.
Neurology(R) neuroimmunology & neuroinflammation
Lack of Antinuclear Antibodies in Convalescent Coronavirus Disease 2019 Patients With Persistent Symptoms.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Rapid sequential development and rupture of mycotic aneurysms within a period of days in a patient with graft-versus-host disease and angiotropic Scedosporium apiospermum infection.
Surgical neurology international
Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy.
The Journal of clinical investigation
SARS-CoV-2 and Mitochondrial Proteins in Neural-Derived Exosomes of COVID-19.
Annals of neurology
First-in-human immunoPET imaging of HIV-1 infection using 89Zr-labeled VRC01 broadly neutralizing antibody.
Nature communications
Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID-19.
Annals of clinical and translational neurology
Persistence, Magnitude, and Patterns of Postacute Symptoms and Quality of Life Following Onset of SARS-CoV-2 Infection: Cohort Description and Approaches for Measurement.
Open Forum Infectious Diseases
Characterizing the COVID-19 Illness Experience to Inform the Study of Post-acute Sequelae and Recovery.
International journal of behavioral medicine
LB8. Lower SARS-CoV-2 IgG and Pseudovirus Neutralization Titers Post-mRNA Vaccination among People Living with HIV.
Open Forum Infectious Diseases
Markers of Immune Activation and Inflammation in Individuals With Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
The Journal of infectious diseases
Long-term immunologic effects of SARS-CoV-2 infection: leveraging translational research methodology to address emerging questions.
Translational research : the journal of laboratory and clinical medicine
A High Percentage of People With Human Immunodeficiency Virus (HIV) on Antiretroviral Therapy Experience Detectable Low-Level Plasma HIV-1 RNA Following Coronavirus Disease 2019 (COVID-19).
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
TNF-α inhibition in the setting of undiagnosed HIV infection: a call for enhanced screening guidelines.
AIDS (London, England)
SARS-CoV-2 serology across scales: a framework for unbiased seroprevalence estimation incorporating antibody kinetics and epidemic recency.
medRxiv : the preprint server for health sciences
SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay.
Science advances
Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease.
Open Forum Infectious Diseases
Interpreting and addressing suboptimal immune responses after COVID-19 vaccination in solid-organ transplant recipients.
The Journal of clinical investigation
Citywide serosurveillance of the initial SARS-CoV-2 outbreak in San Francisco using electronic health records.
Nature communications
multiSero: open multiplex-ELISA platform for analyzing antibody responses to SARS-CoV-2 infection.
medRxiv : the preprint server for health sciences
Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection.
Nature biotechnology
Characterizing the COVID-19 illness experience to inform the study of post-acute sequelae and recovery: a qualitative study.
medRxiv : the preprint server for health sciences
Rapid implementation of a cohort for the study of post-acute sequelae of SARS-CoV-2 infection/COVID-19.
medRxiv : the preprint server for health sciences
SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay.
medRxiv : the preprint server for health sciences
Long-Term SARS-CoV-2-Specific Immune and Inflammatory Responses Across a Clinically Diverse Cohort of Individuals Recovering from COVID-19.
medRxiv : the preprint server for health sciences
Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo.
Journal of virology
Persistent COVID-19-associated neurocognitive symptoms in non-hospitalized patients.
Journal of neurovirology
Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19.
Journal of leukocyte biology
969. TNF-alpha inhibition in the setting of undiagnosed HIV infection: a call for enhanced screening guidelines.
Open Forum Infectious Diseases
Treatment of immunocompromised COVID-19 patients with convalescent plasma.
Transplant infectious disease : an official journal of the Transplantation Society
Total-Body PET Imaging in Infectious Diseases.
PET clinics
Universal Polymerase Chain Reaction and Antibody Testing Demonstrate Little to No Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in a Rural Community.
Open Forum Infectious Diseases
Everolimus, an mTORC1/2 inhibitor, in ART-suppressed individuals who received solid organ transplantation: A prospective study.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection.
medRxiv : the preprint server for health sciences
Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community.
medRxiv : the preprint server for health sciences
From Berlin to London: HIV-1 Reservoir Reduction Following Stem Cell Transplantation.
Current HIV/AIDS reports
Clinical outcomes and serologic response in solid organ transplant recipients with COVID-19: A case series from the United States.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Outcomes of immunomodulatory and biologic therapy in people living with HIV.
AIDS (London, England)
Biosensing: Tunable Fano-Resonant Metasurfaces on a Disposable Plastic-Template for Multimodal and Multiplex Biosensing (Adv. Mater. 19/2020).
Advanced Materials
Tunable Fano-Resonant Metasurfaces on a Disposable Plastic-Template for Multimodal and Multiplex Biosensing.
Advanced materials (Deerfield Beach, Fla.)
Circulating CD30+CD4+ T Cells Increase Before Human Immunodeficiency Virus Rebound After Analytical Antiretroviral Treatment Interruption.
The Journal of infectious diseases
Cerebrospinal fluid soluble CD30 elevation despite suppressive antiretroviral therapy in individuals living with HIV-1.
Journal of Virus Eradication
HIV-1 Coreceptor Usage and Variable Loop Contact Impact V3 Loop Broadly Neutralizing Antibody Susceptibility.
Journal of virology
Defining cerebrospinal fluid HIV RNA escape: editorial review AIDS.
AIDS (London, England)
OP 3.1 Differential decay of intact and defective proviral DNA in HIV-1-infected individuals on suppressive antiretroviral therapy.
Journal of Virus Eradication
OP 4.2 Characterising ‘exceptional’ control among HIV elite controllers.
Journal of Virus Eradication
Rapid development of HIV elite control in a patient with acute infection.
BMC infectious diseases
Seeing Is Believing: Nuclear Imaging of HIV Persistence.
Frontiers in immunology
CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals.
Pathogens & immunity
Transient loss of detectable HIV-1 RNA following brentuximab vedotin anti-CD30 therapy for Hodgkin lymphoma.
Blood advances
Inconsistent HIV reservoir dynamics and immune responses following anti-PD-1 therapy in cancer patients with HIV infection.
Annals of oncology : official journal of the European Society for Medical Oncology
Progress towards obtaining an HIV cure: slow but sure.
Current opinion in HIV and AIDS
NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell transplantation.
Blood advances
Dolutegravir intensification and HIV persistence: 3 + 1 = 3.
The lancet. HIV
Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30.
PLoS pathogens
Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization: Methods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Human Immunodeficiency Virus Type 1 Persistence Following Systemic Chemotherapy for Malignancy.
The Journal of infectious diseases
Correction: Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV.
PLoS pathogens
High-throughput Characterization of HIV-1 Reservoir Reactivation Using a Single-Cell-in-Droplet PCR Assay.
EBioMedicine
Measuring the Size of the Latent Human Immunodeficiency Virus Reservoir: The Present and Future of Evaluating Eradication Strategies.
The Journal of infectious diseases
INTERACTIVE MEDICAL CASE. A Woman with Dyspnea and Altered Mental Status.
The New England journal of medicine
Advances in biosensing strategies for HIV-1 detection, diagnosis, and therapeutic monitoring.
Advanced drug delivery reviews
Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV.
PLoS pathogens
Ethics of ART interruption after stem-cell transplantation.
The lancet. HIV
PP 10.1 Predicting determinants of long-term HIV control with gene therapy strategies.
Journal of Virus Eradication
Real-time predictions of reservoir size and rebound time during antiretroviral therapy interruption trials for HIV.
Journal of Virus Eradication
CCR5-Δ32 Heterozygosity, HIV-1 Reservoir Size, and Lymphocyte Activation in Individuals Receiving Long-term Suppressive Antiretroviral Therapy.
The Journal of infectious diseases
Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1.
Open Forum Infectious Diseases
Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics.
Proceedings of the National Academy of Sciences of the United States of America
Printed Flexible Plastic Microchip for Viral Load Measurement through Quantitative Detection of Viruses in Plasma and Saliva.
Scientific reports
HIV eradication: is cord blood the answer?
The lancet. HIV
Viremic control and viral coreceptor usage in two HIV-1-infected persons homozygous for CCR5 Δ32.
AIDS (London, England)
Emerging technologies for point-of-care management of HIV infection.
Annual review of medicine
Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases.
Annals of internal medicine
Prevention of HIV-1 transmission with postexposure prophylaxis after inadvertent infected blood transfusion.
AIDS (London, England)
Genome-Wide Association Study of Human Immunodeficiency Virus (HIV)-1 Coreceptor Usage in Treatment-Naive Patients from An AIDS Clinical Trials Group Study.
Open Forum Infectious Diseases
Nanostructured optical photonic crystal biosensor for HIV viral load measurement.
Scientific reports
Early treatment and HIV-1 reservoirs: a stitch in time?
The Journal of infectious diseases
Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation.
The Journal of infectious diseases
HIV-1 entry inhibitors: recent development and clinical use.
Current opinion in virology
Low-level detection and quantitation of cellular HIV-1 DNA and 2-LTR circles using droplet digital PCR.
Journal of virological methods
HIV-2 encephalitis: case report and literature review.
AIDS patient care and STDs
Differential use of CCR5 by HIV-1 clinical isolates resistant to small-molecule CCR5 antagonists.
Antimicrobial agents and chemotherapy
Impact of age, gender, and pregnancy on syphilis screening using the Captia Syphilis-G assay.
Sexually transmitted diseases
HIV-1 clinical isolates resistant to CCR5 antagonists exhibit delayed entry kinetics that are corrected in the presence of drug.
Journal of virology
Evolution of CCR5 antagonist resistance in an HIV-1 subtype C clinical isolate.
Journal of acquired immune deficiency syndromes (1999)
Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions.
The Journal of infectious diseases
Instantaneous inhibitory potential is similar to inhibitory quotient at predicting HIV-1 response to antiretroviral therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Infectious granulomatous dermatitis associated with Rothia mucilaginosa bacteremia: A case report.
The American Journal of dermatopathology
Disseminated Geotrichum candidum infection in a patient with relapsed acute myelogenous leukemia following allogeneic stem cell transplantation and review of the literature.
Transplant infectious disease : an official journal of the Transplantation Society
Clinical risk factors for severe Clostridium difficile-associated disease.
Emerging infectious diseases
Lymphoma diagnosis and plasma Epstein-Barr virus load during vicriviroc therapy: results of the AIDS Clinical Trials Group A5211.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Association of alcohol abuse and injection drug use with immunologic and virologic responses to HAART in HIV-positive patients from urban community health clinics.
Journal of community health
Geographic dynamics of viral encephalitis in Thailand.
Microbes and infection
Hantaan virus antibody prevalence in rodent populations of several provinces of northeastern Thailand.
Tropical medicine & international health : TM & IH
Medaka eyeless is the key factor linking retinal determination and eye growth.
Development (Cambridge, England)
The conditional medaka mutation eyeless uncouples patterning and morphogenesis of the eye.
Development (Cambridge, England)