Director
Professor and Director of Radiopharmaceutical Research in teh Department of Radiology and Biomedical Imaging
Honors and Awards
Paul C. Aebersold Award, SNMMI, 2023
Western Pioneer Award, Western Regional SNMMI, 2022
Fellow, Society of Radiopharmaceutical Sciences, SRS, 2021
Michael J. Welch Award, RPSC, SNMMI, 2020
MSBI Outstanding Teacher Award 2019, '21, '23, UCSF MSBI Program, 2019-2023
Distinguished Investigator, Acad Radiol & Biomed Imag Res, 2018
Fellow, Society of Nuclear Medicine and Molecular Imaging, SNMMI, 2018
Editor-in-Chief, Molecular Imaging, 2011-2025
SNM Presidents Distinguished Service Award, Society of Nuclear Medicine, 2010
Alexander Hollaender Distinguished Postdoctoral Fellow, US Department of Energy, 1990-1992
Publications
Proceedings: PET Drugs-A 2023 Workshop on Product Quality, Regulatory Submissions, Facility Inspections, and Benefit-Risk Considerations.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Reply to "Foregoing Nonclinical Dosimetry Studies to Support First-in-Human Studies of Certain PET Radiopharmaceuticals".
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Evaluation of 134Ce/134La-PSMA-617 for PET Imaging and Auger Electron Therapy of Prostate Cancer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Effective Treatment of Disseminated Prostate Cancer Using CD46-Targeted 225Ac Therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Computational Modeling to Advance Novel Medical Isotopes for Radiotheranostics: A DOE-NIH Joint Workshop Executive Summary.
Radiation research
FDA Reconsiders Rules Around Radiation Dosimetry for First-in-Human Studies of Investigational PET Radiopharmaceuticals.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
First-in-human healthy volunteer dosimetry studies of the excitatory amino acid transporter 2 (EAAT2) PET imaging tracer methyl N4-(7-[18F]fluoro-9H-fluoren-2-yl)asparaginate, [18F]RP-115.
Nuclear Medicine and Biology
PET Imaging Using 89Zr-Labeled StarPEG Nanocarriers Reveals Heterogeneous Enhanced Permeability and Retention in Prostate Cancer.
Molecular cancer therapeutics
A Feasibility Study of [18F]F-AraG Positron Emission Tomography (PET) for Cardiac Imaging-Myocardial Viability in Ischemia-Reperfusion Injury Model.
Molecular imaging and biology
Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection.
Science translational medicine
[18F]F-AraG imaging reveals association between neuroinflammation and brown- and bone marrow adipose tissue.
Communications biology
PLX038A, a long-acting SN-38, penetrates the blood-tumor-brain-barrier, accumulates and releases SN-38 in brain tumors to increase survival of tumor bearing mice.
Scientific reports
Prostate-Specific Membrane Antigen Targeted StarPEG Nanocarrier for Imaging and Therapy of Prostate Cancer.
Advanced healthcare materials
CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Development of CD46 targeted alpha theranostics in prostate cancer using 134Ce/225Ac-Macropa-PEG4-YS5.
Theranostics
[11C]Paraoxon: Radiosynthesis, Biodistribution and In Vivo Positron Emission Tomography Imaging in Rat.
The Journal of pharmacology and experimental therapeutics
Author Correction: SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).
Nature immunology
SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).
Nature immunology
Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19.
medRxiv : the preprint server for health sciences
Evaluation of 134Ce/134La as a PET Imaging Theranostic Pair for 225Ac α-Radiotherapeutics.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
A feasibility study for quantitative assessment of cerebrovascular malformations using flutriciclamide ([18F]GE-180) PET/MRI.
Frontiers in medicine
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism.
Cell metabolism
PSMA-Targeted Nanotheranostics for Imaging and Radiotherapy of Prostate Cancer.
Pharmaceuticals (Basel, Switzerland)
Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers.
ACS applied materials & interfaces
Biodistribution of a Mitochondrial Metabolic Tracer, [18F]F-AraG, in Healthy Volunteers.
Molecular imaging
Imaging joint infections using D-methyl-11C-methionine PET/MRI: initial experience in humans.
European journal of nuclear medicine and molecular imaging
Evaluating Radioactive Analogs of Doxorubicin to Quantify ChemoFilter Binding and Whole-Body Positron Emission Tomography/Magnetic Resonance Imaging for Drug Biodistribution.
Journal of vascular and interventional radiology : JVIR
First-in-human immunoPET imaging of HIV-1 infection using 89Zr-labeled VRC01 broadly neutralizing antibody.
Nature communications
Proceedings: PET Drugs-A Workshop on Inspections Management and Regulatory Considerations.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Synthesis and Preliminary Biological Assessment of Carborane-Loaded Theranostic Nanoparticles to Target Prostate-Specific Membrane Antigen.
ACS applied materials & interfaces
Longitudinal Imaging of T Cells and Inflammatory Demyelination in a Preclinical Model of Multiple Sclerosis Using 18F-FAraG PET and MRI.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Biological Distribution and Metabolic Profiles of Carbon-11 and Fluorine-18 Tracers of VX- and Sarin-Analogs in Sprague-Dawley Rats.
Chemical research in toxicology
Total-Body PET Imaging in Infectious Diseases.
PET clinics
Positron Emission Tomography Imaging of Functional Transforming Growth Factor β (TGFβ) Activity and Benefit of TGFβ Inhibition in Irradiated Intracranial Tumors.
International journal of radiation oncology, biology, physics
The Synthesis and Structural Requirements for Measuring Glucocorticoid Receptor Expression In Vivo with (±)-11C-YJH08 PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
An Analysis of Isoclonal Antibody Formats Suggests a Role for Measuring PD-L1 with Low Molecular Weight PET Radiotracers.
Molecular imaging and biology
Positron emission tomography evaluation of oxime countermeasures in live rats using the tracer O-(2-[18 F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate [18 F]-VXS.
Annals of the New York Academy of Sciences
124I-MIBG PET/CT to Monitor Metastatic Disease in Children with Relapsed Neuroblastoma.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography.
ACS chemical biology
Arabinofuranose-derived positron-emission tomography radiotracers for detection of pathogenic microorganisms.
Journal of labelled compounds & radiopharmaceuticals
PET/CT Imaging of Human TNFα Using [89Zr]Certolizumab Pegol in a Transgenic Preclinical Model of Rheumatoid Arthritis.
Molecular imaging and biology
High Enantiomeric Excess In-Loop Synthesis of d-[methyl-11C]Methionine for Use as a Diagnostic Positron Emission Tomography Radiotracer in Bacterial Infection.
ACS infectious diseases
PET Imaging of the EPR Effect in Tumor Xenografts Using Small 15 nm Diameter Polyethylene Glycols Labeled with Zirconium-89.
Molecular cancer therapeutics
Seeing Is Believing: Nuclear Imaging of HIV Persistence.
Frontiers in immunology
Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy.
Molecular pharmaceutics
Divergent synthesis of organophosphate [11C]VX- and [11C]Sarin-surrogates from a common set of starting materials.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Imaging of Activated T Cells as an Early Predictor of Immune Response to Anti-PD-1 Therapy.
Cancer research
Positron emission tomography studies of organophosphate chemical threats and oxime countermeasures.
Neurobiology of disease
Enzymatically Catalyzed Radiofluorination of Biomolecules.
Methods in molecular biology (Clifton, N.J.)
Phase I Study of CTT1057, an 18F-Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate-Specific Membrane Antigen in Prostate Cancer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Radiosynthesis of O-(1-[18 F]fluoropropan-2-yl)-O-(4-nitrophenyl)methylphosphonate: A novel PET tracer surrogate of sarin.
Journal of labelled compounds & radiopharmaceuticals
A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors.
Molecular cancer therapeutics
Radiosynthesis, ex Vivo Biodistribution, and in Vivo Positron Emission Tomography Imaging Evaluations of [11C]2-Pyridinealdoxime Methiodide ([11C]2-PAM): A First-In-Class Antidote Tracer for Organophosphate Intoxication.
ACS chemical neuroscience
Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI.
Chemical communications (Cambridge, England)
Quantification of 89 Zr-Iron oxide nanoparticle biodistribution using PET-MR and ultrashort TE sequences.
Journal of magnetic resonance imaging : JMRI
[11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism.
ACS infectious diseases
A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant.
Cancer research
An improved radiosynthesis of O-(2-[18 F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate: A first-in-class cholinesterase PET tracer.
Journal of labelled compounds & radiopharmaceuticals
An updated synthesis of [11 C]carfentanil for positron emission tomography (PET) imaging of the μ-opioid receptor.
Journal of labelled compounds & radiopharmaceuticals
Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging.
The Analyst
11C-L-methyl methionine dynamic PET/CT of skeletal muscle: response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy.
Annals of nuclear medicine
In Vivo PET Imaging of the Activated Immune Environment in a Small Animal Model of Inflammatory Arthritis.
Molecular imaging
Optimization of an endovascular magnetic filter for maximized capture of magnetic nanoparticles.
Biomedical microdevices
Structure-Activity Relationship of (18)F-Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET Imaging of Prostate Cancer.
Journal of medicinal chemistry
[(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice.
Molecular imaging and biology
Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine.
Brain : a journal of neurology
Site-Specific Radiofluorination of Biomolecules with 8-[(18)F]-Fluorooctanoic Acid Catalyzed by Lipoic Acid Ligase.
ACS chemical biology
[(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography.
Chemical communications (Cambridge, England)
Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging.
Chemical communications (Cambridge, England)
Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography.
Bioconjugate chemistry
Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography.
Nature communications
Simultaneous (68)Ga-DOTA-TOC PET/MRI with gadoxetate disodium in patients with neuroendocrine tumor.
Abdominal imaging
A high-affinity [(18)F]-labeled phosphoramidate peptidomimetic PSMA-targeted inhibitor for PET imaging of prostate cancer.
Nuclear Medicine and Biology
Somatostatin imaging of neuroendocrine-differentiated prostate cancer.
Clinical nuclear medicine
Synthesis and evaluation of constrained phosphoramidate inhibitors of prostate-specific membrane antigen.
Bioorganic & medicinal chemistry letters
A boronate-caged [¹⁸F]FLT probe for hydrogen peroxide detection using positron emission tomography.
Journal of the American Chemical Society
Regulatory Requirements for PET Drug Production.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
A novel fluorine-18 β-fluoroethoxy organophosphate positron emission tomography imaging tracer targeted to central nervous system acetylcholinesterase.
ACS chemical neuroscience
Photons across medicine: relating optical and nuclear imaging.
Biomedical optics express
Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer.
Cancer research
Imaging a functional tumorigenic biomarker in the transformed epithelium.
Proceedings of the National Academy of Sciences of the United States of America
Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model.
Molecular imaging and biology
Approach to assessing myocardial perfusion in rats using static [13N]-ammonia images and a small-animal PET.
Molecular imaging and biology
In memoriam: Michael John Welch, Ph.D 1939-2012.
Molecular imaging and biology
The Q43L mutant of neuregulin 2β is a pan-ErbB receptor antagonist.
The Biochemical journal
Accepting the torch.
Molecular imaging
Myocardial uptake of 7'-(Z)-[(123)I]iodorotenone during vasodilator stress in dogs with critical coronary stenoses.
Circulation. Cardiovascular imaging
FDA cGMP requirements for PET drugs.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas.
Cancer research
Metabolic stability of 6,7-dialkoxy-4-(2-, 3- and 4-[18F]fluoroanilino)quinazolines, potential EGFR imaging probes.
Bioorganic & medicinal chemistry
Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.
Clinical cancer research : an official journal of the American Association for Cancer Research
CGMP for PET drugs: important steps to take now.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Radiolabeled small molecule protein kinase inhibitors for imaging with PET or SPECT.
Molecules (Basel, Switzerland)
Radiation dose estimation using preclinical imaging with 124I-metaiodobenzylguanidine (MIBG) PET.
Medical physics
Design of targeted cardiovascular molecular imaging probes.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen-targeted imaging agent for prostate cancer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Introduction to special issue.
Molecular imaging
Development of an optimized activatable MMP-14 targeted SPECT imaging probe.
Bioorganic & medicinal chemistry
Advancing molecular imaging from the laboratory to everyday practice.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Bruce H. Hasegawa, PhD, 1951-2008.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Session 2: strategies for fast-track technological development and regulatory issues.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Molecular imaging update: advances in MI of the brain.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Mitochondrial avid radioprobes. Preparation and evaluation of 7'(Z)-[125I]iodorotenone and 7'(Z)-[125I]iodorotenol.
Nuclear Medicine and Biology
Anilinodialkoxyquinazolines: screening epidermal growth factor receptor tyrosine kinase inhibitors for potential tumor imaging probes.
Journal of medicinal chemistry
A new precursor for the preparation of 6-[18F]Fluoro-L-m-tyrosine ([18F]FMT): efficient synthesis and comparison of radiolabeling.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Kinetic analysis of 18F-fluorodihydrorotenone as a deposited myocardial flow tracer: comparison to 201Tl.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Exemption of radiopharmaceuticals from <797>.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
No effect of age and estrogen on aromatic L- amino acid decarboxylase activity in rhesus monkey brain.
Neurobiology of aging
Assessment of cancer-associated biomarkers by positron emission tomography: advances and challenges.
Disease markers
Kinetic analysis of 125I-iodorotenone as a deposited myocardial flow tracer: comparison with 99mTc-sestamibi.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
A novel MPTP primate model of Parkinson's disease: neurochemical and clinical changes.
Brain research
An in vivo microdialysis study of striatal 6-[18F]fluoro-L-m-tyrosine metabolism.
Neurochemical research
Iodine-123-5-iodo-6-nitroquipazine: SPECT radiotracer to image the serotonin transporter.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
PET studies of cerebral glucose metabolism in conscious rhesus macaques.
Neurobiology of aging
Synthesis and tissue biodistribution of [omega-11C]palmitic acid. A novel PET imaging agent for cardiac fatty acid metabolism.
Journal of medicinal chemistry
In vivo imaging of the 5-hydroxytryptamine reuptake site in primate brain using single photon emission computed tomography and [123I]5-iodo-6-nitroquipazine.
European journal of pharmacology
Titration of the in vivo uptake of 16 alpha-[18F]fluoroestradiol by target tissues in the rat: competition by tamoxifen, and implications for quantitating estrogen receptors in vivo and the use of animal models in receptor-binding radiopharmaceutical deve
Nuclear Medicine and Biology
16 beta-([18F]fluoro)estrogens: systematic investigation of a new series of fluorine-18-labeled estrogens as potential imaging agents for estrogen-receptor-positive breast tumors.
Journal of medicinal chemistry
Fluorine-18-labeled progestin ketals: synthesis and target tissue uptake selectivity of potential imaging agents for receptor-positive breast tumors.
Journal of medicinal chemistry
Synthesis, radiolabeling and tissue distribution of 11 beta-fluoroalkyl- and 11 beta-fluoroalkoxy-substituted estrogens: target tissue uptake selectivity and defluorination of a homologous series of fluorine-18-labeled estrogens.
Nuclear Medicine and Biology
Fluorine-substituted corticosteroids: synthesis and evaluation as potential receptor-based imaging agents for positron emission tomography of the brain.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
Preparation and evaluation of 17-ethynyl-substituted 16 alpha-[18F]fluoroestradiols: selective receptor-based PET imaging agents.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
20-[18F]fluoromibolerone, a positron-emitting radiotracer for androgen receptors: synthesis and tissue distribution studies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
11 beta-methoxy-, 11 beta-ethyl- and 17 alpha-ethynyl-substituted 16 alpha-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity.
Journal of medicinal chemistry
Synthesis and tissue distribution of fluorine-18 labeled trifluorohexadecanoic acids. Considerations in the development of metabolically blocked myocardial imaging agents.
Bioconjugate chemistry
Binding of 16 alpha-[18F]fluoro-17 beta-estradiol to alphafetoprotein in Sprague-Dawley female rats affects blood levels.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology